How Does Amantadine work?

Amantadine works by inhibiting the ability of the virus to unfold a critical protein so it can’t replicate. Resistance to amantadine is increasingly common; it works by inhibiting the operation of a single protein, and it requires only a single nucleotide mutation to confer resistance in the majority of influenza strains which circulate among humans.  Consequently, amantadine resistance arises relatively easily from previously non-resistant strains.

When should I take Amantadine?

Amantadine is most effective if taken within 24 hours of the first onset of the flu symptoms it is also effective if used prophylactically – taken as a precaution after a possible exposure to flu, but before any symptoms appear.

What are the side effects of Amantadine?

Common side affect of Amantadine are:

  • Appetite loss
  • blurred vision
  • constipation
  • diarrhoea
  • dizziness
  • drowsiness
  • dry mouth & nose
  • headache
  • light-headedness
  • nausea
  • strange dreams
  • tiredness
  • trouble sleeping